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Plastic Surgery

Polynucleotides

Polynucleotides represent a new generation of biostimulants that not only hydrate and refresh the skin, but also stimulate its deep regeneration.

Description of the procedure

Polynucleotides represent a new generation of biostimulants that not only hydrate and refresh the skin, but also stimulate its deep regeneration. These are DNA fragments obtained from a fish source (sterile, highly purified and biocompatible), which act as natural activators of cell renewal, increase collagen synthesis and improve skin structure.

In our Polyclinic, we use Plinest and Newest – two lines from the renowned Italian manufacturer Mastelli, a pioneer in the field of regenerative medicine.

  • Plinest is ideal for the face, neck and décolleté when the goal is to improve texture, elasticity and tone.

  • Newest combines polynucleotides with hyaluronic acid for additional hydration and a “fresh face” effect.

The treatment is carried out by injecting the preparation with tiny injections into the middle layer of the skin, which achieves intensive revitalization without changing the volume.

Candidates

This treatment is ideal for anyone who wants:

  • reduce the first signs of aging (fine lines, loss of radiance)

  • improve skin quality – texture, firmness and elasticity

  • recover the skin after aesthetic procedures (lasers, peels, dermabrasion)

  • restore healthy skin after stress, fatigue, smoking or excessive sun exposure

  • lighten acne scars and restore sensitive skin

Polynucleotides are suitable for all skin types and all age groups – they are especially recommended for people between the ages of 30 and 55 who want a natural approach to rejuvenation.

Preparation

It is necessary to thoroughly cleanse the face and remove makeup before the treatment.

Before the start of the treatment, the doctor will perform a detailed skin examination and, if necessary, apply anesthetic cream for a more comfortable experience during the application.

It is also recommended that you do not take blood-thinning medications (e.g. aspirin, ibuprofen, omega-3), as well as alcohol, for a few days before treatment, to reduce the risk of bruising.

After removing the anesthetic cream, the face is cleaned again and the application of the selected biostimulator can be started.

The application itself takes a short time – on average 15 to 30 minutes – depending on the region and type of preparation. Recovery is minimal, and most patients can return to daily activities immediately.

Procedure progress

The treatment lasts about 20 to 30 minutes and is performed using very fine needles, which minimizes discomfort. An anesthetic cream is applied if necessary. The preparation is applied in a series of microinjections in a specific pattern, depending on the area and goal of the treatment.

Immediately after the treatment , mild redness, small dots or slight swelling may occur, which will subside within a few hours to a day or two at most. You can return to your daily activities immediately after the treatment .

For optimal results , a series of 3 to 4 treatments is recommended, spaced 2 to 3 weeks apart, with occasional “touch-up” treatments every 3 to 6 months.

Recovery

Polynucleotide treatment is a minimally invasive aesthetic procedure with very short or almost no recovery time . Most clients return to their daily activities immediately after the procedure.

Possible reactions include:

  • slight redness at the injection site

  • mild swelling or tenderness

  • small spots or bruises, especially in more sensitive skin

These reactions are mild, transient and expected , and usually disappear within 24 to 48 hours . If minor bruising occurs, it can be easily covered with makeup the next day.

Recommendations after treatment:

  • avoid intense physical activity and sun exposure for at least 24 hours

  • do not apply makeup for the first 12 hours

  • do not touch or massage the treated area

  • avoid saunas, solariums and swimming pools for 2–3 days

In the days following the treatment, the skin may appear tighter, and the true results become visible gradually – as regeneration begins from within , which is the key advantage of this treatment. After a series of treatments, the skin becomes more elastic, fuller, healthier-toned and visibly rejuvenated – in a natural way.

Precautions

Among the more significant side effects, an allergic reaction to the product may occur, which is extremely rare since it is a natural ingredient.

In the hands of inexperienced, unprofessional doctors and insufficient knowledge of facial anatomy, necrosis of a part of the skin can occur. However, it is important to know that this side effect can be prevented by timely and rapid reaction, because it is a truly terminal stage preceded by many symptoms that you can recognize on your own. It is extremely rare throughout the world.

In the event of any side effects, the doctors at the Bagatin Polyclinic are at your disposal and you can contact them, consult by phone and email, or come for a check-up.

After treatment with dermal fillers, going to the sauna, sun exposure, going to the solarium, pressing the part of the face that has been treated is not recommended in the short term.

Price

The package at the Bagatin Polyclinic includes the price of the preparation itself, the preparation and treatment procedure, and, if necessary, a check-up after 2 weeks.

In cooperation with banks, Bagatin Polyclinic provides the option of paying in installments, as well as interest-free payments up to a certain number of installments.

You can check more about payment methods and treatment prices in the current price list of the Bagatin Polyclinic:

Find out the price of the treatment

They said about us...

All praise to the experienced doctor Tomica, who quickly and professionally explained everything related to solving my problem. Kudos to the kind nurses too!

G.B.

"Dr. Kramarić has an incredible sense of proportion and detail. She made subtle adjustments that brought freshness back to my face without losing my expression. I didn't look 'filled out', but simply - rested and natural. And most importantly - I feel better in my own skin."

O.B.

"Treatments with Dr. Ina have become a little ritual of self-care for me. Her expertise, gentle approach, and attention to every detail make a huge difference. My forehead is smoother, my smile is fresher, and my sense of self-confidence is priceless."

P.P.

The most beautiful lip augmentation ever by Dr. Kramarić! I can't wait to get rid of my wrinkled forehead too.

J.R.

"With Dr. Haris, I felt for the first time that a doctor really listens to what you need – not only aesthetically, but also emotionally. I wanted to maintain my expressions, but refresh my look and reduce wrinkles on my forehead. The result is beyond expectations – subtle, natural, without stiffness. I feel younger, but without being 'unrecognizable'."

T.T.

Your

Frequently asked questions

1. What is the difference between Plinest and Newest treatments?

Plinest contains pure polynucleotides and is ideal for regenerating, tightening and improving skin tone , especially the face, neck and décolleté.

Newest combines polynucleotides with hyaluronic acid , providing an additional moisturizing effect and “plump” appearance of the skin.

The choice of product depends on the condition of the skin and the desired results – and our doctors recommend the most suitable option after an examination.

2. When are the first results visible?

The first effects (increased hydration and radiance) are visible after the first treatment , but the full regenerative effect comes gradually – over several weeks, as the skin renews itself from within. Optimal results are achieved after 3–4 treatments spaced 2–3 weeks apart .

3. How many treatments are needed?

For best results, it is recommended:

  • 3 to 4 treatments in a row

  • maintaining results every 4 to 6 months , depending on age and skin condition

Your doctor will individually create a treatment plan according to your skin’s goals and needs.

4. Can it be combined with other treatments?

Absolutely! Polynucleotides are often combined with:

  • mesotherapy

  • dermal fillers

  • microneedling

  • lasers or chemical peels

They are also ideal for preparing the skin for aesthetic procedures or recovering after them , as they promote healing and strengthen the skin barrier.

Book your treatment now!

Polynucleotides