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Plastic Surgery

Biostimulators

Biostimulators are innovative aesthetic treatments that stimulate the skin's natural renewal processes, with the aim of long-term improvement of its structure, elasticity and glow.

Description of the procedure

Unlike classic dermal fillers that provide the skin with immediate volume, biostimulators work gradually – stimulating the own production of collagen and elastin, the key proteins responsible for the skin’s youthful appearance.

These treatments are intended for people who want a natural and refreshed look , without losing facial expression and without excessive changes. The results are subtle but long-lasting , with visible improvements that come gradually, in accordance with the skin’s biological rhythm.

Unlike classic dermal fillers that provide the skin with immediate volume, biostimulators work gradually – stimulating the own production of collagen and elastin, the key proteins responsible for the skin’s youthful appearance.

These treatments are intended for people who want a natural and refreshed look , without losing facial expression and without excessive changes. The results are subtle but long-lasting , with visible improvements that come gradually, in accordance with the skin’s biological rhythm.

Types of biostimulators

  • Poly-L-lactic acid (PLLA/PDLLA)

    Poly-L-lactic acid is a powerful biostimulator that works by gradually stimulating the production of new collagen. It does not act like a classic filler – it does not provide instant volume – but is used to gradually tighten, firm and restore facial contours.

    Lisnina is often used for deeper biostimulation and volumization in the middle and lower part of the face.

    Juvelook is a newer formulation that combines PLLA with hyaluronic acid - ideal for thinner areas such as the skin around the eyes and neck, as it provides both hydration and regeneration.

    Ideal for: face, neck, eye area, loss of volume and sagging skin.
    Results: gradual and long-lasting, visible after 6–8 weeks and lasting up to 2 years.


  • Calcium hydroxyapatite (CaHA)

    CaHA is a mineral similar to that in bones and teeth, which acts as a physical carrier of volume and a powerful biostimulator.

    Radiesse is used to contour the face, hands, jawline and neck, as it provides an instant lift and collagen stimulation.

    HArmonyCA is an innovative combination of hyaluronic acid and CaHA, which provides immediate volume and long-term renewal - often used for faces with pronounced signs of aging.

    Ideal for: cheekbones, jawline, neck, décolleté and hands.
    Results: immediate effect with progressive improvement over 2–3 months.

  • Polynucleotides (PN)

    Polynucleotides are DNA fragments that are biologically active at the cellular level - they promote tissue repair, hydration, microcirculation and antioxidant protection.

    Plinest is a classic line for deep regeneration and revitalization of the skin.

    Newest is a more advanced formula with additional components for increased skin elasticity and density.

    Ideal for: face, dark circles, neck, décolleté, areas with signs of fatigue and sun damage.
    Results: visible improvement in skin texture and tone within 2–4 weeks, full effect in 6–8 weeks.

  • Amino acids

    Sunekos combines low-molecular hyaluronic acid and specific amino acids that together stimulate the synthesis of collagen and elastin. It is particularly effective on thin, sensitive and problematic areas, such as the area around the eyes.
    It works gently but effectively – without creating volume – so it is also ideal for preventive treatments for younger skin.

    Ideal for: dark circles, neck, cheek wrinkles, décolletage.
    Results: visible refreshment and improvement in skin tone after just 2 treatments.

  • Hyaluronic formulas with biostimulating components

    Profhilo is a unique product that contains stabilized hyaluronic acid of high and low molecular weight, without additional chemical compounds. It does not create volume, but acts as a biological stimulator of skin hydration, tone and elasticity.
    The application is carried out on precisely defined 5 points on each side of the face, which makes the treatment an extremely fast and safe option for all skin types.

    Ideal for: face, neck, décolleté, upper arms.
    Results: natural "glow effect" and visibly tightened, hydrated skin after just 2 treatments 4 weeks apart.

Among the best-known and most commonly used biostimulators are HarmonyCa, Profhilo and Sunekos , each with its own unique properties and mode of action.

HarmonyCa is a calcium hydroxyapatite-based biostimulator that, in addition to stimulating collagen, also provides a facial contouring effect. Thanks to its structure, it works on deep wrinkles and sagging skin, restoring its natural lifting and firmness.

On the other hand, Profhilo uses an innovative formula with a high concentration of hyaluronic acid that deeply hydrates the skin and stimulates its regeneration. This preparation is particularly effective in areas where the skin is thin and sensitive, such as the neck and décolleté, as it improves tone and elasticity without adding volume.

For those who value not only hydration but also the stimulation of collagen and elastin production, Sunekos is ideal. This biostimulator combines hyaluronic acid with amino acids, which provides a multiple effect on skin quality, reducing fine wrinkles and restoring youthful radiance.

These three products, although different, have a common goal – revitalizing the skin in a natural way, with long-lasting results achieved by stimulating its own regenerative processes.

Candidates

Biostimulators are the ideal solution for anyone who wants gradual, natural and long-lasting skin rejuvenation , without exaggerated volume or an artificial appearance. This treatment is an increasingly common choice for both women and men who want to improve the quality of their skin in a subtle but effective way.

It is most often recommended for people who notice the first signs of aging – loss of elasticity, the appearance of fine lines and a dull skin tone. It is also very effective for more pronounced changes, such as sagging skin, reduced volume in the cheeks or jaw , as well as wrinkles on the neck and décolleté . Biostimulators are not limited to the face – they are also excellent for treating hands, upper arms and other areas that often show their age.

Thanks to their regenerative effects, biostimulators are an increasingly common choice for young people who want to prevent skin aging and maintain its tone and freshness throughout the years.

They are especially suitable for those who want to:

  • stimulate the skin’s own renewal processes without injecting volume,

  • improve skin texture and tone,

  • act on sun damage or dehydration,

  • treat sensitive and demanding areas such as under-eye circles, neck and décolleté.

Preparation

It is necessary to thoroughly cleanse the face and remove makeup before the treatment.

Before the start of the treatment, the doctor will perform a detailed skin examination and, if necessary, apply anesthetic cream for a more comfortable experience during the application.

It is also recommended that you do not take blood-thinning medications (e.g. aspirin, ibuprofen, omega-3), as well as alcohol, for a few days before treatment, to reduce the risk of bruising.

After removing the anesthetic cream, the face is cleaned again and the application of the selected biostimulator can be started.

The application itself takes a short time – on average 15 to 30 minutes – depending on the region and type of preparation. Recovery is minimal, and most patients can return to daily activities immediately.

Procedure progress

Treatment with biostimulators begins after the face is cleaned and, if necessary, anesthetic cream is applied for greater comfort.

After the anesthetic takes effect, the doctor carefully injects the selected biostimulator into the targeted layers of the skin – most often into the dermis or subdermis, depending on the type of preparation and the desired effect.

The application technique and amount of preparation are individually adjusted to each patient, and the procedure itself lasts from 15 to 30 minutes.

Slight discomfort is possible during the treatment, but thanks to the expertise of our medical team and the use of top-quality products, the treatment is extremely well tolerated.

After the procedure, the skin is cleaned again and a soothing cream is applied.

Recovery

After treatment, mild reactions at the application site are possible – such as redness, swelling or sensitivity – which usually disappear within 24 to 48 hours.

In most cases, patients can return to their daily activities immediately.

For optimal results, we recommend that:

  • Do not touch the treated area for at least a few hours after the treatment.

  • avoid strenuous physical activity, sauna and solarium for 24–48 hours after treatment,

  • do not expose your face to direct sunlight and be sure to use a cream with a protective factor.

Results develop gradually, as the skin’s natural regeneration process is activated, and the full effect can be expected within a few weeks, depending on the type of biostimulator.

For a longer-lasting effect, an individually planned maintenance schedule is recommended, which the doctor will suggest after the initial treatment.

Precautions

Among the more significant side effects, an allergic reaction to the product may occur, which is extremely rare since it is a natural ingredient.

In the hands of inexperienced, unprofessional doctors and insufficient knowledge of facial anatomy, necrosis of a part of the skin can occur. However, it is important to know that this side effect can be prevented by timely and rapid reaction, because it is a truly terminal stage preceded by many symptoms that you can recognize on your own. It is extremely rare throughout the world.

In the event of any side effects, the doctors at the Bagatin Polyclinic are at your disposal and you can contact them, consult by phone and email, or come for a check-up.

After treatment with dermal fillers, going to the sauna, sun exposure, going to the solarium, pressing the part of the face that has been treated is not recommended in the short term.

Price

The package at the Bagatin Polyclinic includes the price of the preparation itself, the preparation and treatment procedure, and, if necessary, a check-up after 2 weeks.

In cooperation with banks, Bagatin Polyclinic provides the option of paying in installments, as well as interest-free payments up to a certain number of installments.

You can check more about payment methods and treatment prices in the current price list of the Bagatin Polyclinic:

Find out the price of the treatment

They said about us...

All praise for Dr. Snježana Kramarić!

H.Č.

Everything was great, Dr. Snježana Kramarić was really great.

L.F.

Dr. Haris Varupa is very kind and nice! Only praise.

E.G.

The most beautiful lip augmentation ever by Dr. Kramarić! I can't wait to get rid of my wrinkled forehead too.

J.R.

Your

Frequently asked questions

1. How do biostimulants work?

Biostimulators stimulate fibroblasts in the skin to produce their own collagen and other key proteins, resulting in long-term skin rejuvenation and revitalization.

2. Which parts of the face and body can be treated with biostimulators?

Biostimulators are used for the face (cheeks, cheekbones, neck), décolletage, hands, as well as for improving the quality of the skin on other parts of the body.

3. When are the results visible?

The results are gradual and become visible after a few weeks, with the maximum effect achieved 2 to 3 months after treatment.

4. Are there any side effects or contraindications?

Side effects are rare and mostly mild, such as redness, swelling or bruising that quickly resolve. The treatment is not recommended for pregnant women, nursing mothers, people with active inflammatory processes or allergies to the ingredients.

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Biostimulators